Endocrine Abstracts

Introduction: Reduced health-related quality of life (HRQoL) is common in patients with chronic hypoparathyroidism treated conventionally with active vitamin D and calcium supplements.Aim: To determine the HRQoL of patients with hypoparathyroidism with disease persisting for more than 1 year.Methods: We identified 32 patients (women/men − 31/1, median (Me) age 48 years [38; 59.5]). The average duration of the disease was 4 ye...

Hypoparathyroidism (HP) is a rare disease characterized by an absence or inappropriately low concentrations of circulating parathyroid hormone, leading to hypocalcaemia, hypophosphatemia and elevated urinary calcium excretion.Aim: To determine complications in chronic post-surgical HP patients.Material and methods: We have analyzed the data from 76 patients (71 women and 5 men; median age 51.8 years (range 18–77)) with chronic...

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder resulting from oversecretion of parathyroid hormone (PTH) in parathyroid glands. Hypocalcemia can occur in the postoperative period after parathyroidectomy (PTE) and can be challenging to control and requires varying doses of supplementation. Vitamin D deficiency can worsen the severity of PHPT and promote the development of “hungry bone syndrome” due to increased influx of calcium into bon...

Introduction: Reduced health-related quality of life (HRQoL) is common in patients with hypoparathyroidism (HypoPT) treated conventionally with calcium and active vitamin D supplements.Aim: we studied the HRQoL in patients with chronic HypoPT estimated with the 36-Item Short-Form Health Survey (SF-36) and multidimensional fatigue inventory (MFI-20).Methods: 64 patients with chronic HypoPT (women/men – 57/7, median age 47[36;59...

Background: Chronic hypoparathyroidism is a relatively rare disease associated with various complications. The analysis of large databases of patients with chronic hypoparathyroidism is a necessary tool to enhance quality of medical care, as well as to determine the therapeutic approaches and prognostic markers of the disease.Aims: To describe complications associated with chronic hypoparathyroidism and determine predictors of their development according...

Introduction: Normocalcemic primary hyperparathyroidism (NPHPT) is defined as a condition in which persistently normal serum calcium levels are observed in the presence of high levels of parathyroid hormone (PTH). NPHPT is a new entity which possibly represents a clinically symptomatic disease and which has generated a considerable scientific interest.Aim: To compare the clinical and laboratory data between the normocalcemic and hypercalcemic forms of PH...

Objective: Postsurgical hypoparathyroidism (HypoPT) is the most common etiology of disease and often occurs after thyroid surgery. However, the differential diagnosis between different forms of HypoPT in some cases remains a challenge. We present the clinical case of postsurgical and functional HypoPT combination.Case description: A 44-year-old female was referred to the Endocrinology Research Centre. She underwent total thyroidectomy for follicular aden...

BackgroundHypoparathyroidism is a rare disorder characterized by hypocalcemia and hyperphosphatemia due to absent or inadequate parathyroid hormone secretion. Data on effective treatment strategies and predictors of long-term complications have only recently began to emerge. The epidemiological information regarding chronic hypoparathyroidism in Russia is strictly limited that prompted this research.AimsTo es...

IntroductionVitamin D deficiency is considered as a major public health concern. Due to vitamin D’s crucial role in the intestinal calcium absorption, its deficiency may result in hypocalcemia and in a spectrum of associated clinical manifestations.AimTo assess the effect of 25(OH) vitamin D level (25(OH)D) on the frequency of hypocalcemia episodes and the daily profile of serum calcium and 24-h urinary ...

Background: In some patients with primary hyperparathyroidism (PHPT), glomerular filtration rate (GFR) demonstrate decrease after parathyroidectomy (PTE). GFR may decrease immediately after surgery due to general anesthesia, but after a month not all patients restore kidney function; a decreased GFR is also observed after 1–2 years after surgery.Aim: To find the pre-surgical factors of GFR decrease after PTE.Methods: Patients ...